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Taipale M, Rea S, Richter Okay, Vilar A, Lichter P, Imhof A, Akhtar A: hMOF histone acetyltransferase is required for histone H4 lysine 16 [acetylation](https://git.17pkmj.com3000/etsukobeeman3/isabell2024/wiki/Lowering-your-medical-cover-expenses-is-a-top-priority-for-many-families-in-the-current-year.) in mammalian cells.
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As an illustration, human SET7/9 has not too long ago been reported to methylate Lys189 in the normal transcription issue TAF10, leading to an elevated affinity for RNA polymerase II and transcriptional activation of sure TAF10-dependent genes 37 SET7/9 has additionally been reported to methylate p53, growing the stability of this quick lived tumor-suppressor protein 38 These observations suggest that we should always not narrowly define the SET-area proteins as histone lysine methyltransferases however as a substitute name them protein lysine methyltransferases.
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These important functions may be related to MOF-mediated acetylation of chromatin-associated proteins other than H4 or alterations of chromatin construction induced by such modifications that are not detectable by DNaseI sensitivity.
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